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Selected Publications


(1) Utzman, P. H.; Mays, V. P.; Miller, B. C.; Fairbanks, M. C.; Brazelton, W. J.; Horvath, M. P. Metagenome Mining and Functional Analysis Reveal Oxidized Guanine DNA Repair at the Lost City Hydrothermal Field. PLoS ONE 2024 19(5): e0284642. https://doi.org/10.1371/journal.pone.0284642

(2) Demir, M.; Russelburg, L. P.; Lin, W.-J.; Trasviña-Arenas, C. H.; Huang, B.; Yuen, P. K.; Horvath, M. P.; David, S. S. Structural Snapshots of Base Excision by the Cancer-Associated Variant MutY N146S Reveal a Retaining Mechanism. Nucleic Acids Res. 2023, gkac1246. https://doi.org/10.1093/nar/gkac1246.

(3) Russelburg, L. P.; O’Shea Murray, V. L.; Demir, M.; Knutsen, K. R.; Sehgal, S. L.; Cao, S.; David, S. S.; Horvath, M. P. Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY. ACS Chem. Biol. 2020, 15 (1), 93–102. https://doi.org/10.1021/acschembio.9b00639.

(4) Woods, R. D.; O’Shea, V. L.; Chu, A.; Cao, S.; Richards, J. L.; Horvath, M. P.; David, S. S. Structure and Stereochemistry of the Base Excision Repair Glycosylase MutY Reveal a Mechanism Similar to Retaining Glycosidases. Nucleic Acids Res. 2016, 44 (2), 801–810. https://doi.org/10.1093/nar/gkv1469.

(5) Shyam, R.; Gorusupudi, A.; Nelson, K.; Horvath, M. P.; Bernstein, P. S. RPE65 Has an Additional Function as the Lutein to Meso-Zeaxanthin Isomerase in the Vertebrate Eye. Proc. Natl. Acad. Sci. U. S. A. 2017, 114 (41), 10882–10887.  https://doi.org/10.1073/pnas.1706332114.

(6) Horvath, M. P.; George, E. W.; Tran, Q. T.; Baumgardner, K.; Zharov, G.; Lee, S.; Sharifzadeh, H.; Shihab, S.; Mattinson, T.; Li, B.; Bernstein, P. S. Structure of the Lutein-Binding Domain of Human StARD3 at 1.74 Å Resolution and Model of a Complex with Lutein. Acta Crystallogr. Sect. F Struct. Biol. Commun. 2016, 72 (Pt 8), 609–618. https://doi.org/10.1107/S2053230X16010694.

(7) Horvath, M. P.; Schweiker, V. L.; Bevilacqua, J. M.; Ruggles, J. A.; Schultz, S. C. Crystal Structure of the Oxytricha Nova Telomere End Binding Protein Complexed with Single Strand DNA. Cell 1998, 95 (7), 963–974. https://doi.org/10.1016/s0092-8674(00)81720-1.